Silvia B. Ramos, MD PhD
We are interested in interconnecting medical standpoints with basic research concepts to ask relevant scientific questions. As an MD/PhD, I have the training and experience to approach these questions from both clinical and basic science perspectives. I acquired clinical experience treating patients as a clinical immunologist in Brazil and in the US as a clinical embryologist at UNC. My PhD training was in Immunology. During my post-doctoral work at NIEHS-NIH in Dr. Perry Blackshear lab, using genetically-engineered mouse models, my findings led me to the intriguing field of reproductive biology and female infertility. We brought this new research endeavor implicating the role of Zinc Finger Protein 36 Like 2 (ZFP36L2, “L2”) an RNA-binding protein in mouse infertility to set up an independent research program at UNC-CH in the Department of Obstetrics and Gynecology, and run the clinical IVF lab. Then, most of our time was devoted to clinical activities and in acquiring knowledge and advanced skills on human embryology. In 2010, by passing the ABB examination, I became a fully certified Embryology Lab Director. In 2012, I obtained an NICHD K08 award, mentored and co-mentored by Drs. William Marzluff and Kathleen Caron, respectively. The K08 project proposal was planned to focus on the Leukemia Inhibitory Factor during early embryo implantation, however, we observed novel L2 functions in vivo related to ovarian infertility: ovulation and oocyte maturation defects. Thus, we adjusted to follow the biological lead towards the ovarian function. In July 2014, I joined the Department of Biochemistry and Biophysics. Our work has been scientifically recognized as exemplified by receiving a NSF Talk Award at the FASEB RNA Decay meeting in 2018 and an RNA travel award in 2019 to present recent findings at the RNA Society meeting in Poland. As a NIH new investigator, to successfully accomplish the goals of our research proposal, we count on a multidisciplinary team comprising accomplished UNC colleagues from departments of Biology and Bioinfromatics, Chemistry, Biochemistry and Pharmacology. We also stablished collaborations with Dr. JoAnne Richards from Baylor Medical School and Dr. Tomohiko Murase from Nagoya University. I am delighted to lead our research team and extend our collaborations, with the goal of defining the molecular functions of L2-mediated mRNA turnover in female infertility.
A full list of my publications can be found here.
Hilal Hekimoglu, upcoming visiting PhD Student
Received her B.S. in Biological Sciences and Bioengineering from International University of Sarajevo and a M.S. in Genetics at Istanbul University, where under the mentorship of Dr. Selcuk Sozer Tokdemir, she studied thrombotic effects of JAK2V617F mutation in endothelial cells. She is third year PhD student in Istanbul University Genetics Department. She is interested in hematological malignancies, cancer stem cells, immunogenomics and gene therapy. In her off hours, she likes to listen to music, cooking and hanging out with family.
Ian C. Redmon, UNC Undergrad
Is a senior undergraduate at UNC majoring in Chemistry with a focus in biochemistry. As a part of the Ramos lab, I am currently working on monitoring the levels of certain hormones at various stages of sexual development in mice, in order to help characterize the mechanism of infertility associated with the gene Zfp36L2. He chose this project as highly appealing to him, as it offered him the independence of his own project, as well as a very close-knit lab group for whenever guidance needed. Through research, he is honing down his interests for what he would like to pursue as a career, as well as gaining the necessary experience for success in graduate school.
Is a second-year undergraduate student majoring in Biochemistry at the University of North Carolina at Chapel Hill. He first got interested in biochemistry and molecular biology while taking coursework at the NC School of Science and Mathematics. He is fascinated by biochemical processes that happen at a molecular level and how these molecular processes influence physiology and disease. His research interest began in high school while taking a research and lab intensive coursework. He plans on doing undergraduate research through his senior year towards developing a Senior Honors Thesis. He plans to pursue either a PhD or an MD/PhD after graduation.
Colony Management Core (CMC) team, Janee Cadlett-Jette our Colony Management Specialist
The Colony Management Core (CMC) was founded in 2014 with the mission of accommodating labs by managing all their breeding needs. The Core prides itself on assisting with common issues such as overproduction and providing productive outcomes for difficult strains. CMC if fully staffed with a PhD manager and a variety of AALAS accredited supervisor, specialists, and technicians. Supervisor Janee Cadlett-Jette has had the pleasure of working alongside the Ramos lab since 2017. After graduating from North Carolina Agricultural and Technical State University she has been furthering her knowledge and career in the field of animal science since 2010. Janee began working at UNC in 2015 and has played an intricate role in the start of CMC. She continues to enjoy working with the Ramos lab and hopes to further the success of her team and the research community.